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  • Acute chest syndrome (ACS) in sickle cell disease . . . - UpToDate
    Acute chest syndrome (ACS) is defined as a new radiodensity on chest imaging accompanied by fever and or respiratory symptoms It is an acute complication of sickle cell disease (SCD) that is potentially fatal and requires immediate intervention regardless of the patient's age
  • Acute Chest Syndrome - StatPearls - NCBI Bookshelf
    Acute chest syndrome is a dangerous complication of sickle cell disease characterized by a new radiodensity on chest imaging accompanied by respiratory symptoms and possibly fever [1] Acute chest syndrome occurs when various factors in individuals with sickle cell disease trigger vaso-occlusion within the pulmonary vasculature [2] While acute chest syndrome can occur in any sickle cell disease
  • Acute Chest Syndrome in Children with Sickle Cell Disease
    In the prospective multicenter Cooperative Study of Sickle Cell Disease (CSSCD), younger age, lower fetal hemoglobin (HbF) concentration, higher steady-state Hb, and higher steady-state white blood cell (WBC) counts were found to be significant risk factors for ACS 36 Those with more severe genotypes (HbSS and HbSβ 0 thalassemia) had a greater risk of developing ACS than the milder ones
  • STSTN Guidelines for the Diagnosis and Management of Acute . . .
    It is largely a clinical diagnosis, particularly in the initial stages, and diagnosis is straightforward when with the usual clinical features present to an experienced clinician The diagnosis can be difficult to make when there is a lag between radiological features, and in cases with less clear clinical features The clinical features of ACS
  • Acute chest syndrome in patients with sickle cell disease
    American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support Blood Adv (2020) 4 (2): 327 - 355 Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members JAMA 2014 Sep 10; 312(10):1033-48 Standards for the Clinical Care of Adults with Sickle Cell Disease in the UK
  • Acute Chest Syndrome in Sickle Cell Disease - ScienceDirect
    The clinical diagnosis of ACS is defined as an acute illness with a new segmental pulmonary infiltrate consistent with consolidation, but not atelectasis, along with 1 or more new respiratory symptoms or signs such as cough, chest pain, fever (>38 5 °C), hypoxemia (>3% decrease in oxygen saturation from a documented steady-state value on room
  • Acute chest syndrome in sickle cell – Primary Care Notebook
    study evidence showed that 50% of patients with sickle cell crises in the lung, had a pain event in the two weeks preceding the event (3) around half of all SCD patients will experience at least one episode of ACS during their lives (4) in some areas, the acute chest syndrome is the commonest cause of death in sickle cell anaemia





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