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  • Orienting of attention, pupil size, and the norepinephrine system
    We examined this suggestion by measuring participants' pupil size, which has been demonstrated to correlate with the LC–NE system, while they performed cuing tasks We found a response-locked phasic dilation of the pupil in the discrimination task, as compared with the localization task, which may reflect different firing modes of the LC–NE
  • From pupil to the brain: New insights for studying cortical . . .
    In this minireview, we will focus on the evidence supporting the importance of the LC-NE system in modulating brain plasticity Given the close relationship between LC-NE tone and pupil size (Joshi et al , 2016), we will also explore pupillometry as a non-invasive method for studying cortical plasticity An overview of the LC-NE system
  • Pupil Size as a Window on Neural Substrates of Cognition
    Other indirect evidence for a pupil–LC link has come from studies that used pharmacological approaches to perturb the LC-NE system, resulting in pupil changes [42] Together, these studies provided enough indirect evidence that, even before extensive measurements of relationships between pupil size and LC neural activity were obtained, the
  • Pupil Size as a Window on Neural Substrates of Cognition
    Here, we review findings that have identified key roles for three neural systems: cortical modulation of the pretectal olivary nucleus (PON), which controls the pupillary light reflex; the superior colliculus (SC), which mediates orienting responses, including pupil changes to salient stimuli; and the locus coeruleus (LC)-norepinephrine (NE
  • Pupil Dilation Dynamics Track Attention to High-Level . . .
    As the LC is the sole source of NE-releasing fibers to the forebrain , and pupils can dilate with latencies as short as 200 ms , pupil size over time should provide an overt and objective measure of NE levels in the forebrain on a sub-second time-scale
  • Changes in pupil dilation and P300 amplitude indicate the . . .
    During the tasks, continuous pupil diameter and EEG were recorded We found that psychological flow and two presumed indicators of the phasic LC-NE activity (pupil dilation and EEG P300 amplitude
  • More than Meets the Eye: the Relationship between Pupil Size . . .
    This means that either: 1) an as yet unidentified projection from LC to brain stem nuclei exists, 2) projections from the LC to autonomic control centers in the hypothalamus drive changes in pupil size (Smith et al , 2006), or 3) the effects of stimulation are due to antidromic activation of upstream areas that do control pupil size This final





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