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  • Dendritic Cells and Their Role in Immunotherapy - PMC
    Dendritic cells have long been a focus of cancer immunotherapy due to their role in inducing protective adaptive immunity, but cancer vaccines have shown limited efficacy in the past With the advent of immune checkpoint blockade and the ability to identify patient-specific neoantigens, new vaccines, and combinatorial therapies are being
  • Dendritic cells in cancer immunology and immunotherapy
    A phase I clinical trial of CD1c (BDCA-1)+ dendritic cells pulsed with HLA-A ∗ 0201 peptides for immunotherapy of metastatic hormone refractory prostate cancer J Immunother 38 , 71–76 (2015)
  • In vivo dendritic cell reprogramming for cancer immunotherapy
    The success of cancer immunotherapy can be limited by mechanisms that tumors develop to evade destruction by the immune system Tumors can block the activation and obstruct the ability of immune cells (dendritic cells and T lymphocytes) to destroy the tumor, thereby creating an environment that is beneficial for cancer growth
  • Dendritic cell biology and its role in tumor immunotherapy
    As crucial antigen presenting cells, dendritic cells (DCs) play a vital role in tumor immunotherapy Taking into account the many recent advances in DC biology, we discuss how DCs (1) recognize pathogenic antigens with pattern recognition receptors through specific phagocytosis and through non-specific micropinocytosis, (2) process antigens into small peptides with proper sizes and sequences
  • Clinical use of dendritic cells for cancer therapy
    Since the mid-1990s, dendritic cells have been used in clinical trials as cellular mediators for therapeutic vaccination of patients with cancer Dendritic cell-based immunotherapy is safe and can induce antitumour immunity, even in patients with advanced disease However, clinical responses have been disappointing, with classic objective tumour response rates rarely exceeding 15%
  • Cancer immunotherapy via dendritic cells - PMC - National Center for . . .
    DCs and cancer immunotherapy a | Random targeting of dendritic cells (DCs) in ‘endogenous’ vaccination results from in vivo antigen release owing to immunogenic cell death in response to chemotherapy, radiotherapy and immunomodulation approaches that are targeted at T cells
  • Dendritic cells as orchestrators of anticancer immunity and immunotherapy
    Dendritic cells (DCs) can induce adaptive anticancer immunity mainly via uptake and presentation of tumour-associated antigens, migration to lymph nodes and T cell priming, and recruitment and
  • Dendritic Cell-Based Immunotherapy: The Importance of Dendritic Cell . . .
    Dendritic cells (DCs) are specialized antigen-presenting cells that are crucial for maintaining self-tolerance, initiating immune responses against pathogens, and patrolling body compartments Despite promising aspects, DC-based immunotherapy faces


















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