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  • McArdle Disease (GSD5): What It Is, Symptoms Treatment
    McArdle disease is a genetic (inherited) condition Specifically, mutations (changes) in the PYGM gene cause it Normally, the PYGM gene provides instructions for your body to make an enzyme called myophosphorylase (muscle glycogen phosphorylase)
  • PYGM gene - MedlinePlus
    The PYGM gene provides instructions for making an enzyme called myophosphorylase This enzyme breaks down a complex sugar called glycogen Myophosphorylase is one of three related enzymes called glycogen phosphorylases that break down glycogen in cells
  • Myophosphorylase - Wikipedia
    Myophosphorylase or glycogen phosphorylase, muscle associated (PYGM) is the muscle isoform of the enzyme glycogen phosphorylase and is encoded by the PYGM gene This enzyme helps break down glycogen (a form of stored carbohydrate) into glucose-1-phosphate (not glucose), so it can be used within the muscle cell
  • PYGM Gene - GeneCards | PYGM Protein | PYGM Antibody
    PYGM (Glycogen Phosphorylase, Muscle Associated) is a Protein Coding gene Diseases associated with PYGM include Glycogen Storage Disease V and Glycogen Storage Disease Among its related pathways are Activation of cAMP-Dependent PKA and Glycogen metabolism
  • Muscle Glycogen Phosphorylase and Its Functional Partners in . . .
    Muscle glycogen phosphorylase (PYGM) differs from other PG isoforms in expression pattern and biochemical properties The main role of PYGM is providing sufficient energy for muscle contraction However, it is expressed in tissues other than muscle, such as the brain, lymphoid tissues, and blood
  • Glycogen Storage Disease Type V - GeneReviews® - NCBI Bookshelf
    Glycogen storage disease type V (GSDV, McArdle disease) is a metabolic myopathy characterized by exercise intolerance manifested by rapid fatigue, myalgia, and cramps in exercising muscles Symptoms are usually precipitated by isometric exercise or sustained aerobic exercise
  • Entry - *608455 - GLYCOGEN PHOSPHORYLASE, MUSCLE; PYGM - OMIM
    The PYGM gene encodes the muscle isoform of glycogen phosphorylase (EC 2 4 1 1), which catalyzes and regulates the breakdown of glycogen to glucose-1-phosphate during glycogenolysis This metabolic pathway is necessary for the generation of ATP during physical activity (Gautron et al , 1987)





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