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  • The CLIC GEEC pathway regulates particle uptake and formation of the . . .
    We propose a model in which internalization of HIV-1 particles together with CLIC GEEC membranes leads to the formation of the VCC in HIV-infected macrophages, creating an intracellular platform that facilitates further particle assembly and budding
  • The CLIC GEEC pathway regulates particle endocytosis and formation of . . .
    We identified an endocytosis 61 pathway that helps to explain the origins of the VCC, the CLIC GEEC pathway Inhibition 63 prevented the VCC from forming in HIV-infected macrophages The GTPase dynamin-2 64 was also required for delivery of HIV particles to the VCC This study identifies a new
  • What is the CLIC GEEC Endocytosis pathway? - Mechanobiology Institute . . .
    The CLIC GEEC (CG) pathway is a clathrin-independent endocytic pathway mediated by uncoated tubulovesicular primary carriers called clathrin-independent carriers (CLICs) which arise directly from the plasma membrane and later mature into tubular early endocytic compartments called Glycosylphosphotidylinositol- anchored protein (GPI-AP) enriched
  • Massive endocytosis mechanisms are involved in uptake of HIV-1 . . .
    The CLIC GEEC pathway regulates particle endocytosis and formation of the virus-containing compartment (VCC) in HIV-1-infected macrophages bioRxiv (2024) doi: 10 1101 2024 09 05 611375
  • HIV-1 Particle Capture and VCC Formation in Microglia
    Experiments in Aim 1 will define the mechanism of HIV particle capture and uptake by microglia and compare these to MDMs The role of Siglec-1 and virion membrane gangliosides will be determined, and the role of inflammatory stimuli on capture and uptake quantified
  • Science Cast
    We propose a model in which internalization of HIV-1 particles together with CLIC GEEC membranes leads to the formation of the VCC in HIV-infected macrophages, creating an intracellular platform that facilitates further particle assembly and budding
  • PLoS Pathogens Issue Image | Vol. 21(3) April 2025
    HIV-1 virus-like particles (red) captured by Siglec-1 (magenta) were taken into the macrophage within tubules of the CLIC GEEC pathway (CD98 staining, green) This study demonstrates that CLIC GEEC-mediated endocytosis of particles leads to the formation of the VCC and contributes to cell-cell spread of HIV
  • The CLIC GEEC pathway regulates particle endocytosis and formation of . . .
    Inhibition of the CLIC GEEC pathway prevented virus-like particle delivery to the VCC and prevented the VCC from forming in HIV-infected macrophages The GTPase dynamin-2 was also required for delivery of HIV particles to the VCC
  • The CLIC GEEC pathway regulates particle endocytosis and formation of . . .
    We propose a model in which internalization of HIV-1 particles together with CLIC GEEC membranes leads to the formation of the VCC in HIV-infected macrophages, creating an intracellular platform that facilitates further particle assembly and budding
  • The CLIC GEEC pathway regulates particle uptake and formation of the . . .
    We propose a model in which internalization of HIV-1 particles together with CLIC GEEC membranes leads to the formation of the VCC in HIV-infected macrophages, creating an intracellular platform that facilitates further particle assembly and budding





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